How to win with the biological weapon in brutal mode in Plague Inc.
Plague Inc. is a simulation game in which the player must create and spread a disease to destroy humanity. One of the available options is to use a biological weapon, which can be extremely effective if used correctly.
In this guide, I'll provide you with a detailed strategy on how to win with the biological weapon in brutal mode in Plague Inc. I'll give you tips on how to create your disease, how to spread it quickly, and how to avoid attracting the attention of international organizations.
How does the biological weapon work in Plague Inc.?
The biological weapon in Plague Inc. is a special type of disease that is created in a laboratory instead of evolving naturally like other diseases. This means that the player has greater control over the characteristics of their biological weapon than other diseases.
The biological weapon also has some special features that make it more lethal than other diseases. For example, it can be transported through means of transportation such as airplanes, which means it can quickly spread worldwide.
- Please note: Using the biological weapon requires a lot of attention and planning. If you're not sure how to use it correctly, you may end up attracting the attention of international organizations and failing your objective.
Choosing the type of pathogen and genetic abilities
To win in Plague Inc. with the biological weapon in brutal mode, it's important to choose the right type of pathogen and the correct genetic abilities.
Type of pathogen
There are several types of pathogens to choose from: bacteria, viruses, fungi, parasites, and prions. Each of them has unique characteristics that can affect the spread of the disease and the strategies to adopt during the game.
Viruses are extremely contagious but evolve quickly, making it difficult to maintain control over the spread of the disease. Bacteria are less contagious but more resistant to antibiotics, making them an interesting choice if you want to slow down the search for a cure. Fungi can be difficult to spread at first, but once they take root they can expand rapidly. Parasites are difficult to detect and treat, while prions are highly lethal but also very difficult to spread.
Genetic Abilities
Genetic abilities allow the pathogen to evolve and become increasingly resistant to human cures. It's important to choose the right abilities based on the type of pathogen chosen.
- Drug Resistance: increases the pathogen's resistance to antibiotics and cures.
- Cold/Heat Resistance: allows the pathogen to survive in extreme weather conditions.
- Mutation: increases the speed at which the pathogen evolves and adapts to its environment.
- Lethal Symptoms: makes the symptoms of the disease more severe and lethal, accelerating the spread of the disease.
However, the evolution of the pathogen comes at a cost. Every time a genetic ability is chosen, evolution points are consumed. It is important to carefully manage these points to maximize the effectiveness of the pathogen without running out too soon.
In general, a good strategy is to focus on spreading the disease early in the game, using genetic abilities such as airborne or waterborne transmission. Once the disease has spread enough, you can focus on genetic abilities that make the pathogen more resistant to human cures.
With the right combination of pathogen type and genetic abilities, it will be possible to win in Plague Inc. with the biological weapon in brutal mode!
Intermediate Stage: Activating Brutal Mode
After completing the initial stage, it is now time to move on to brutal mode. This mode requires a more aggressive strategy to spread the biological weapon and cause maximum destruction.
1. Choose the Right Type of Disease
In this stage, it is important to choose the type of disease you want to spread. Some diseases are more lethal than others and can spread more quickly. For example, the Black Death is very lethal but can be difficult to spread if you do not have a high level of transmission.
It is also important to consider the symptoms of the disease. Choosing symptoms that cause panic and terror can help spread the disease more quickly. For example, symptoms like respiratory failure or internal bleeding can cause panic among people and push them to seek medical care, thus further spreading the disease.
2. Increase Transmission
To spread the disease more quickly, it is necessary to increase the level of transmission. This can be done through various means such as:
- International Airport: Selecting this option will cause the disease to spread through international flights.
- Water: Selecting this option will cause the disease to spread through contaminated water.
- Insects: Selecting this option will cause the disease to spread through infected insects.
Choosing the right means of transmission can make a difference in how quickly the disease spreads. For example, if you choose an international airport as a means of transmission, it will be easier to spread the disease worldwide.
3. Resist Cures
To ensure that the disease is not easily cured, it is important to resist cures. This can be done through various means such as:
- Genetic Mutation: Genetic mutation makes the disease harder to cure.
- Immune Defense: Immune defense makes people's immune system less effective in fighting the disease.
- Reducing Drug Efficacy: By reducing drug efficacy, cures become less effective against the disease.
Resisting cures can increase the time needed to find a cure and therefore increase the number of infected people and cause further destruction.
Final stage: total eradication of humanity
After spreading the virus worldwide and causing a global pandemic, the final stage is to completely eradicate humanity. This is when you have to be brutal and show no mercy.
1. Evolve lethal symptoms
To kill all human beings, you must evolve lethal symptoms to increase the virulence of your virus. Humans will die quickly if you have symptoms such as organ failure, internal bleeding, and septic shock.
- Organ failure: This symptom attacks the internal organs of humans, leading to their death within a few days.
- Internal bleeding: This symptom causes internal bleeding in humans, leading to their death within a few hours.
- Septic shock: This symptom causes a generalized infection in the body of humans, leading to their death within a few hours.
2. Evolve drug resistance
Humans will try to fight your virus with drugs and treatments. To prevent this from happening, you must evolve drug resistance against drugs used by humans. In this way, your virus will be immune to any attempts at treatment.
3. Increase transmission
To spread the virus more quickly, you must evolve more effective ways of transmission. For example, you can evolve transmission through air or water, so that the virus spreads more quickly and reaches even people living in remote areas.
- Airborne transmission: This method of transmission allows the virus to spread through simple contact with an infected person.
- Waterborne transmission: This method of transmission allows the virus to spread through water sources such as rivers and lakes.
4. Wait and observe
After evolving lethal symptoms, drug resistance, and advanced modes of transmission, it's time to wait and observe. Your virus should now be able to kill all humans on earth within a few months. As soon as you see the number of humans decreasing drastically, you will know that you have won.
Conclusions and practical tips for winning with biological weapons
The brutal mode of Plague Inc. can be very difficult to overcome, especially when choosing to use a biological weapon. However, by following some practical tips, you can increase your chances of success:
- Choose the right country: Start your spread in a country with a large population and that has many air and sea connections to other parts of the world.
- Invest in transmission: Focus on increasing transmission to quickly spread the disease. Invest in symptoms only when you have enough evolution points.
By following these tips, you can increase your chances of winning with the biological weapon in Plague Inc.'s brutal mode. But remember, every game is different and requires a unique strategy!
Finally, don't forget to experiment. There are many variables to consider when playing Plague Inc., so don't be afraid to try new strategies. With a little practice and perseverance, you'll be able to win with the biological weapon even in the game's most difficult mode.

Michael Anderson - Software Engineer
My name is Michael Anderson, and I work as a computer engineer in Midland, Texas.
My passion is sharing my knowledge in various areas, and my purpose is to make education accessible to everyone. I believe it is essential to explain complex concepts in a simple and interesting way.
With GlobalHowTo, I aim to motivate and enrich the minds of those who want to learn.





